Diagram of a disk stack centrifuge rotor (from Alfa Laval).
Centrifugation is the process of separating undissolved particulates from a solution by spinning it at a high speed. Centrifugation uses the principle of sedimentation, accelerating the process by spinning the material to use centrifugal force instead of using gravity. Stacked-disc centrifugation, the type used most often in biopharmaceutical manufacturing, takes this process to a higher level of throughput and effectiveness by multiplying the effective settling area with the use of a stacked set of conical "discs" in the bowl of the centrifuge. Units of this type can spin the bowl at a speed of thousands of RPMs, generating centrifugal forces approaching 10,000 gravities.
Page updated 7/6/17 |
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